Plasma ddPCR detected EGFR and KRAS mutations rapidly with the high specificity needed to select therapy and avoid repeat biopsies. It may also detect EGFR T790M missed by tissue genotyping due to tumor heterogeneity in resistant disease.
The study investigated the sensitivity, specificity, test turnaround time, and robustness of droplet digital polymerase chain reaction–based plasma genotyping for the rapid detection of targetable genomic alterations in patients with advanced non–small-cell lung cancer.
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